Benign hepatocellular tumors: Problem diagnoses and applications of new pathomolecular classifications

Introduction Benign hepatocellular tumors gather 2 separate groups of lesions according to their pathogenesis. Such classification has been successfully achieved owing to molecular studies, especially assessing their biological behaviour. Therefore, one distinguishes polyclonal disorders that concern regenerative non-neoplastic processes, such as focal nodular hyperplasia (FNH), and monoclonal lesions that are consistent with neoplastic tumors, including liver cell adenomas (1, 2). Both lesions are predominantly encountered in young women, usually in the context of oral contraception use.